Min Jae Lee
Professor Seoul National University
Dr. Min Jae Lee is an internationally recognized leader in protein homeostasis research, with seminal contributions to the ubiquitin–proteasome system, autophagy, and translational therapeutic innovation. As Professor of Biochemistry and Molecular Biology at Seoul National University College of Medicine, he has developed novel strategies such as engineered proteasomes and CHIP E3 ligase inhibitors for cancer, neurodegeneration, and fibrosis. He has authored over 130 peer-reviewed publications, received multiple prestigious international awards, and provides global leadership through editorial, academic, and mentorship roles.
Seminars
Thursday 11th June 2026
Directly Engaging 26S Proteasomes for Ubiquitin-Independent Target Degradation
2:00 pm
- Explore how Seoul National university has developed Prote-a-Tac, a targeted protein degradation strategy that directly engages the 26S proteasome, bypassing the need for Ub ligase-mediated polyubiquitination
- Discuss how Prote-a-Tac is a heterobifunctional chimera combining a proteasome-binding module with a target-specific antibody, enabling selective degradation of overexpressed and endogenous proteins
- Outline how the platform is highly modular and specific, allowing flexible target switching and demonstrated high specificity validated by quantitative mass spectrometry
- Discover how the mRNA-based lipid nanoparticle delivery of Prote-a-Tac in cells and mouse xenograft models resulted in effective target degradation and delayed tumor progression
