From Design to Application: A CRBN Molecular Glue Library Derived from In-House and Literature-Validated CRBN Binders
- A systematic exploration of the chemical space of CRBN-binding scaffolds (300 compounds synthesized and tested) , SAR insights and highlighting representative, structurally novel, and effective binders.
- An overview of HitChem’s CRBN molecular glue (MG) library design strategy, along with HTS case studies across multiple targets.