From Design to Application: A CRBN Molecular Glue Library Featuring Diverse & Unique CRBN Binders
- Unveiling how focused library screening remains a primary strategy for identifying and validating hit compounds against emerging targets using the CRBN MG approach, highlighting the need for broader and more diverse glue chemistries to fully explore the “glueable” proteome
- Presenting a systematic exploration of novel CRBN binders and key findings from our discovery efforts
- Sharing how follow-up screening studies using libraries derived from HitChem newly identified binders demonstrated that these compounds can frequently function as effective ternary binders or degraders across multiple targets